For the third time in 13 months, a bike rider was killed yesterday on Houston Street, leading one advocate to label it Manhattan's "boulevard of death."Derek Lake, 23, a filmmaker who had recently bought the bike, was turning onto Houston from LaGuardia Place at 9:20 a.m. Monday when he lost control of his bike in a construction area and was run over by a passing truck. Houston is undergoing a multi-year, $30 million reconstruction, which advocates blamed for Lake's death."It's likely that a metal plate on the street caused him to loose control," said Noah Budnick of Transportation Alternatives. "The plate was in violation of the city's highway rules and the rain made it even more dangerous. The cyclist can only do so much, and in this case the street conditions were the likely contributing factor in the crash."The driver of the truck that hit Lake was cited for six equipment violations, but was not charged with a crime. The city agency overseeing construction along Houston said its records show that the metal plate at that intersection had been removed.A check of the intersection Monday night showed seven mismatched plates on the opposite side of the intersection from where Lake went down.Times Up!, a bike advocacy group, issued a warning for all city cyclists to avoid riding on Houston for the duration of the construction.Lake was a recent graduate of the School of Visual Arts in Manhattan, and had recently begun showing a film he wrote and directed in festivals around the city."He knew being in the film business was a hard thing to do, but he didn't let anyone discourage him," Lake's younger sister Alexis said yesterday. "He was going to make it big."Alexis, 22, said her brother just purchased the bike a few weeks ago to shorten his commute from Brooklyn and to improve his physical fitness."He was the scrawniest kid in the whole world," she recalled, "but joked around about getting pudgy and told me he was getting a bike."In May of last year, Brandie Bailey, 21, was killed while riding a bike on Houston Street when she was struck by a garbage truck.One month later, Andrew Morgan, 25, was also killed on his bike when a truck make an illegal turn on Houston.A police spokesman said Monday that only officers who witness a crash personally can issue a violation to the driver.In none of the recent deaths on Houston was a driver charged with any crime.Another recent cycling fatality was Dr. Carl Nacht, 56, who was struck by an NYPD tow truck while he cycled with his wife in the West Side Highway's bike lane. Nacht died in the hospital Monday.